Fluid Bed Granulation
Granulation to produce larger aggregate granules.
The process of granulation improves material properties such as flowability and compressibility and also avoids segregation of mixture components. There are two common methods of granulation, wet granulation and dry granulation.
Fluid bed granulation is a wet granulation process that involves the addition of a binder liquid to primary particles to form aggregated granulates. The material to be granulated is suspended within the fluid bed granulator by applying high-velocity air across the particles in order to set-up a fluidised bed of material. The binder liquid is then sprayed upon the primary powder at a controlled addition rate which results in the particles adhering to each other and forming larger granulates. Upon completion of the spraying process, the wet granulate is dried within the fluid bed granulator using hot air. During the spraying and drying process, granulates will grow in size and then reduce due to inter granulate collisions which will cause attrition of the agglomerate.
The ability to monitor the granulate growth during binder addition and subsequent size reduction as a result of the drying process is possible with the integration of an Eyecon™ inline on a fluid bed granulator. The Eyecon allows for real-time monitoring of the granulation process which can be used to control and optimise critical process parameters such as binder addition rate, process length, drying time and the end point granulate size.
For further reading on monitoring granulate growth using the Eyecon for a fluid bed granulation process please refer to the application note entitled “Monitoring Fluid Bed Granulation Processes In-Line with Real Time Imaging”.